July 2023 Top Biopharma Deal: Alnylam co-development and co-commercialization deal with Roche for zilebesiran

Aug 1, 2023 | Deal of the Month, Partnership Deals

July 2023 Top Biopharma Deal Upfront
Alnylam co-development and co-commercialization deal with Roche for zilebesiran

Highlighted Deal Financial Comps

Date Announced:

July 24, 2023

Total Deal Value:


Upfront Cash:


Upfront Equity:


Option Payments:


Total Milestones:



Low double-digit royalties outside the U.S.

Cost & Profit Split:

50/50 Profit Share in the US

Deal Synopsis

The Asset:

Alnylam's zilebesiran for the treatment of hypertension

Deal Structure:

Development and Commercialization License

Partnership Features:

Co-Development, Shared Dev Cost , U.S. Co-Commercialization, Shared 50/50

Deal Details:

  • Alnylam grants Roche exclusive worldwide rights to co-develop and co-commercialize zilebesiran for hypertension.
  • Alnylam leads joint clinical development, sharing costs 40% by Alnylam and 60% by Roche.
  • Alnylam receives $310M upfront and up to $2.49B in milestones.
  • Co-commercialization in the U.S. with 50/50 profit split
  • Royalties outside the U.S.

Last Month:

Congrats to Alnylam and Roche for landing DealForma’s July 2023 Top Biopharma Deal. Last month’s Deal of the Month was Astra Zeneca – Quell Therapeutics for C-CAR039 and C-CAR066. Read about it here.

DealForma’s Deal of the Month selection is based on the largest disclosed upfront cash and equity total in partnership deals involving R&D as announced in the month prior to this article. Data for this analysis was compiled using the DealForma biopharma deals database. All data are based on publicly disclosed figures and deal terms.

We invite you to answer interesting questions on biopharma business development and licensing using our data and carefully curated profiles on deals, pipelines, companies, funding, and business executives by visiting dealforma.com to schedule your personalized demo.


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